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抗人CD4，克隆RPA-T4

抗人、黑猩猩CD4的小鼠单克隆IgG1抗体
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产品号 #100-0298_C

抗人、黑猩猩CD4的小鼠单克隆IgG1抗体

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总览
实验数据
产品说明书及文档
应用领域
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总览

RPA-T4抗体可特异性识别CD4。CD4是一种分子量约为59 kDa的单链1型跨膜糖蛋白，属于免疫球蛋白 (Ig) 超级家族。CD4包含四个胞外免疫球蛋白样结构域 (D1-D4)。RPA-T4识别该蛋白的D1结构域，其结构类似于免疫球蛋白可变结构域。CD4在大多数胸腺细胞和T细胞亚群（辅助性T细胞）中表达水平相对较高，而在外周血单个核细胞和巨噬细胞中表达水平较低。CD4与MHC II的非多态性区域结合，并通过增强TCR和MHC II抗原复合物之间的亲和力，在MHC II限制性抗原识别中作为T细胞受体（TCR）的共受体。CD4还通过胞内结构域与细胞质酪氨酸激酶（如Lck）的相互作用，放大从TCR到细胞质的信号。此外，CD4是人类免疫缺陷病毒（HIV）的受体。RPA-T4抗体的结合可阻断HIV结合和混合淋巴细胞反应（MLR），并通过干扰CD4与HLA-DR的结合来抑制体外CD4+ T细胞的激活。它也能部分阻断SK3抗体的结合。研究发现，RPA-T4抗体的表位对甲醛固定敏感。

亚型
一抗
 
靶抗原
CD4
 
别名
Leu3，L3T4，T4
 
活性物种
Chimpanzee，人
 
偶联
APC，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
T 细胞
 
应用
CyTOF，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，Western印迹
 
研究领域
免疫
 
克隆
RPA-T4
 
基因编号
920
 
同种型
IgG1，kappa
 

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Data Figures

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone RPA-T4, APC or a mouse IgG1, kappa APC isotype control antibody.

Figure 1. Data for Anti-Human CD4 Antibody, Clone RPA-T4, APC

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone RPA-T4, APC (filled histogram) or a mouse IgG1, kappa APC isotype control antibody (solid line histogram).

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone RPA-T4, FITC or a mouse IgG1, kappa FITC isotype control antibody.

Figure 2. Data for Anti-Human CD4 Antibody, Clone RPA-T4, FITC

Flow cytometry analysis of human PBMCs labeled with Anti-Human CD4 Antibody, Clone RPA-T4, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (solid line histogram).

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone RPA-T4, PE or a mouse IgG1, kappa PE isotype control antibody.

Figure 3. Data for Anti-Human CD4 Antibody, Clone RPA-T4, PE

Flow cytometry analysis of human PBMCs labeled with Anti-Human CD4 Antibody, Clone RPA-T4, PE (filled histogram) or a mouse IgG1, kappa PE isotype control antibody (solid line histogram).

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone RPA-T4, followed by a goat anti-mouse IgG1 antibody, PE or a mouse IgG1, kappa isotype control antibody, followed by a goat anti-mouse IgG1 antibody, PE.

Figure 4. Data for Anti-Human CD4 Antibody, Clone RPA-T4, Unconjugated

Flow cytometry analysis of human PBMCs labeled with Anti-Human CD4 Antibody, Clone RPA-T4, followed by a goat anti-mouse IgG1 antibody, PE (filled histogram) or a mouse IgG1, kappa isotype control antibody, followed by a goat anti-mouse IgG1 antibody, PE (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, APC
Catalog #
100-0299, 100-0298
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, FITC
Catalog #
100-0302, 100-0301
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, PE
Catalog #
100-0305, 100-0306
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD4, Clone RPA-T4
Catalog #
100-0307
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, APC
Catalog #
100-0299, 100-0298
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, FITC
Catalog #
100-0302, 100-0301
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD4, Clone RPA-T4, PE
Catalog #
100-0305, 100-0306
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD4, Clone RPA-T4
Catalog #
100-0307
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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更多信息
Clone RPA-T4
Gene Id 920
Alternative Names Leu3, L3T4, T4
Isotype IgG1, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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