产品号 #60122_C
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD4
概述
The SK3 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4). The epitope for SK3 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the SK3 antibody blocks HIV binding and mixed lymphocyte reaction (MLR).
Subtype
Primary Antibodies
Target Antigen
CD4, CD5
Reactive Species
Human
Conjugation
PE
Host Species
Mouse
Cell Type
T Cells, T Cells, CD4+, T Cells, Regulatory
Species
Human
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology
Clone
SK3
Gene ID
920
Data Figures
Figure 1. Data for PE Conjugated
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone SK3, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE; solid line histogram).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD4 Antibody, Clone SK3, PE Catalog #
60122PE, 60122PE.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD4 Antibody, Clone SK3, PE Catalog #
60122PE, 60122PE.1 Lot #
All Language
English Resources and Publications
Educational Materials (2)
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