产品号 #60134_C
小鼠单克隆IgG1抗体,抗人CD24
32D12抗体识别CD24,CD24是一种35 - 50 kDa的糖基磷脂酰肌醇(GPI)连接的唾液酸化糖蛋白,被锚定在质膜上,并根据细胞类型发生不同的糖基化。CD24的功能尚未完全确定,但它被认为在淋巴细胞发育中发挥作用,特别是作为CD4+ T细胞的共刺激分子,以及调节B细胞的增殖、活化、分化和凋亡。CD24也可能通过与CD62P (P-选择素)的结合在细胞粘附和转移中起作用。CD24在滤泡树突状细胞、各种上皮细胞和血细胞类型(包括粒细胞、红细胞、大多数B细胞和T淋巴细胞亚群)上均有表达。由于CD24在整个B细胞发育过程中表达,但在分化为浆细胞阶段后丢失,因此CD24可能可以作为B细胞分化标志物。此外,CD24在卵巢癌、乳腺癌、前列腺癌、膀胱癌、肾癌、肺癌、神经母细胞瘤以及各种血液系统恶性肿瘤中都存在高表达,因此也可作为肿瘤预后和诊断的潜在标志物。据报导,32D12抗体识别的表位不同于抗体克隆VIB-C5、VIB-E3、LC66、BA-1、ML5、OKB2和SN3 A5-2H10识别的表位。
亚型
一抗
靶抗原
CD24
别名
CD24a,热稳定抗原,HSA,Ly-52,Nectadrin,小细胞肺癌簇4抗原
活性物种
人
偶联
Biotin 或 生物素,FITC
宿主物种
小鼠
细胞类型
B 细胞
种属
人
应用
细胞分选,流式细胞术
研究领域
免疫
克隆
32D12
基因编号
100133941
同种型
IgG1,kappa
Figure 1. Data for Unconjugated
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12 followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram), or a mouse IgG1, kappa isotype control antibody followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).
Figure 2. Data for Biotin-conjugated
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, Biotin followed by streptavidin (SAV) FITC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin (Catalog #60070BT) followed by SAV FITC (solid line histogram).
Figure 3. Data for FITC-conjugated
Flow cytometry analysis of human perifpheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).
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Species | Human |
---|---|
Clone | 32D12 |
Gene Id | 100133941 |
Alternative Names | CD24a, Heat stable antigen, HSA, Ly-52, Nectadrin, Small cell lung carcinoma cluster 4 antigen |
Isotype | IgG1, kappa |
小鼠单克隆IgG1, kappa同型对照抗体
大鼠单克隆IgG2b抗体,抗小鼠CD24
小鼠单克隆IgG1, kappa同型对照抗体
抗小鼠IgG(H+L)山羊多克隆抗体
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