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Anti-Human CD24 Antibody, Clone 32D12

Mouse monoclonal IgG1 antibody against human CD24

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产品号 #60134_C

Mouse monoclonal IgG1 antibody against human CD24

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Anti-Human CD24 Antibody, Clone 32D12

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概述

实验数据

产品说明书及文档

概述

The 32D12 antibody reacts with CD24, a 35 - 50 kDa glycosylphosphatidylinositol (GPI)-linked sialoglycoprotein that is anchored to the plasma membrane and is glycosylated variably depending on cell type. The function of CD24 has yet to be fully determined but it is believed to play a role in lymphocyte development, particularly in acting as a costimulatory molecule for CD4+ T cells and in regulating B cell proliferation, activation, differentiation, and apoptosis. CD24 may also function in cell adhesion and metastasis, likely through binding of CD62P (P-Selectin). CD24 is expressed by follicular dendritic cells, and various epithelial and hematopoietic cell types, including granulocytes, erythrocytes, most B cells, and subsets of T lymphocytes. As it is expressed throughout B cell development but is lost after differentiation into the plasma cell stage, CD24 may be used as a B cell differentiation marker. Furthermore, CD24 also has the potential to be a marker for tumor prognosis and diagnosis as it is highly expressed in numerous cancers including ovarian, breast, prostate, bladder, renal, and lung, as well as neuroblastomas and various hematological malignancies. Reportedly, the 32D12 antibody recognizes an epitope that is distinct from those recognized by clones VIB-C5, VIB-E3, LC66, BA-1, ML5, OKB2 and SN3 A5-2H10.

Subtype
Primary Antibodies

Target Antigen
CD24

Alternative Names
CD24a, Heat stable antigen, HSA, Ly-52, Nectadrin, Small cell lung carcinoma cluster 4 antigen

Reactive Species
Human

Conjugation
Biotin, FITC

Host Species
Mouse

Cell Type
B Cells

Species
Human

Application
Cell Isolation, Flow Cytometry

Area of Interest
Immunology

Clone
32D12

Gene ID
100133941

Isotype
IgG1, kappa

Data Figures

Figure 1. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12 followed by a rat anti-mouse IgG1 antibody, FITC (filled histogram), or a mouse IgG1, kappa isotype control antibody followed by a rat anti-mouse IgG1 antibody, FITC (solid line histogram).

Figure 2. Data for Biotin-conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, Biotin followed by streptavidin (SAV) FITC (filled histogram), or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, Biotin (Catalog #60070BT) followed by SAV FITC (solid line histogram).

Figure 3. Data for FITC-conjugated

Flow cytometry analysis of human perifpheral blood mononuclear cells (PBMCs; gated on lymphocytes) labeled with Anti-Human CD24 Antibody, Clone 32D12, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).