产品号 #60152_C
Mouse monoclonal IgG1 antibody against human CD235a (glycophorin A)
概述
The 2B7 antibody reacts with CD235a (Glycophorin A), an ~10 kDa type I sialoglycoprotein present in the cell membrane of erythrocytes and erythroid precursors as a homodimer. Glycophorin A bears the antigenic determinants for the MN and Ss blood groups and has been proposed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in circulation. Glycophorin A is first detectable on morphologically recognizable erythroid precursors just after the colony-forming unit erythroid (CFU-E) stage, and reaches its maximal expression at the late normoblast stage. Anti-glycophorin is useful in combination with anti-transferrin receptor (CD71) to identify distinct stages of erythroid differentiation since CD71 expression precedes Glycophorin A expression, but is lost during maturation of normoblasts into mature red blood cells (RBCs). Peptide-binding ELISA data indicate that the epitope of the 2B7 antibody is located in the extracellular domain of CD235a within the sequence Ala54 - Ser66 (AATPRAHEVSEIS).
Subtype
Primary Antibodies
Target Antigen
CD235 (Glycophorin)
Reactive Species
Human
Conjugation
FITC
Host Species
Mouse
Cell Type
Erythroid Cells, Red Blood Cells
Species
Human
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology
Clone
2B7
Gene ID
2993
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
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Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Cord Blood Banking
Resources and Publications
Educational Materials (2)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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