产品号 #100-1353_C
Mouse monoclonal antibody against human, monkey CD137
概述
This mouse monoclonal antibody (clone 4B4-1) reacts with human and monkey CD137, a type I membrane protein and member of the TNF receptor superfamily.
Following activation, it is expressed on multiple immune cells such as natural killer (NK), T, and dendritic cells. CD137 plays a role in cytokine activation, preventing activation-induced cell death and it also plays a role in promoting the activity of cytotoxic T cells. CD137 deficiency in humans has been hypothesized to inhibit differentiation and function of T cells; CD137-deficient mice have been recorded to have impaired T cell cytotoxicity, proliferation, and survival. As an immune stimulator, CD137 can influence the tumor microenvironment by increasing the cytotoxicity of T and NK cells as well as their ability to infiltrate tumors. For these reasons, CD137 represents a strong candidate for cancer immunotherapy. Use this monoclonal antibody in applications requiring detection of CD137, such as flow cytometry (FC).
Following activation, it is expressed on multiple immune cells such as natural killer (NK), T, and dendritic cells. CD137 plays a role in cytokine activation, preventing activation-induced cell death and it also plays a role in promoting the activity of cytotoxic T cells. CD137 deficiency in humans has been hypothesized to inhibit differentiation and function of T cells; CD137-deficient mice have been recorded to have impaired T cell cytotoxicity, proliferation, and survival. As an immune stimulator, CD137 can influence the tumor microenvironment by increasing the cytotoxicity of T and NK cells as well as their ability to infiltrate tumors. For these reasons, CD137 represents a strong candidate for cancer immunotherapy. Use this monoclonal antibody in applications requiring detection of CD137, such as flow cytometry (FC).
Subtype
Primary Antibodies
Target Antigen
CD137
Alternative Names
ILA, 4-1BB, TNFRSF9, CDw137
Reactive Species
Human, Monkey
Conjugation
Biotin, FITC, PE, Unconjugated
Host Species
Mouse
Cell Type
Dendritic Cells, NK Cells, T Cells
Species
Human
Application
Flow Cytometry
Area of Interest
Immunology, Stem Cell Biology
Clone
4B4-1
Gene ID
3604
Isotype
IgG1, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, Biotin Catalog #
100-1354 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, FITC Catalog #
100-1355 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, PE Catalog #
100-1356 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1 Catalog #
100-1353 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, Biotin Catalog #
100-1354 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, FITC Catalog #
100-1355 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1, PE Catalog #
100-1356 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD137 (ILA) Antibody, Clone 4B4-1 Catalog #
100-1353 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Resources and Publications
Educational Materials (2)
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