产品号 #72662_C
雌激素信号通路调节剂；调节选择性雌激素受体和雌激素相关受体活性
总览
他莫昔芬是一种选择性雌激素受体调节剂（SERM），具有组织特异性拮抗或激动作用。受体被激活后，会形成同源或异源二聚体，并与辅助蛋白相互作用来调节基因转录。在转基因条件模型中，他莫昔芬常用来激活Cre-ER。
细胞系开发
·在转基因模型中用于Cre-ER 联合诱导 Cre 介导的重组，Cre-ER 是由 Cre 重组酶与突变型雌激素受体激素结合结构域融合而成的蛋白，特异性结合他莫昔芬而不结合雌激素(Feil et al.; Zhang et al.)。
癌症研究
·抑制人乳腺癌细胞系MCF-7的生长（Katzenellenbogen et al.）。
·乳腺组织和乳腺癌细胞中雌激素受体拮抗剂(Abe et al.; Horwitz et al.)。
细胞类型
癌细胞及细胞系，乳腺细胞，多能干细胞
种属
人，小鼠，非人灵长类，其它细胞系，大鼠
研究领域
癌症，细胞系制备，上皮细胞研究，干细胞生物学
CAS 编号
10540-29-1
化学式
C₂₆H₂₉NO
纯度
≥ 95 %
通路
雌激素
靶点
ER
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
更多信息
| Species | Human, Mouse, Non-Human Primate, Other, Rat |
|---|---|
| Cas Number | 10540-29-1 |
| Chemical Formula | C₂₆H₂₉NO |
| Purity | ≥ 95% |
| Target | ER |
| Pathway | Estrogen |
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to Tamoxifen and its salts which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov
