Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models.
CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.).
CANCER RESEARCH
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
CELL LINE DEVELOPMENT
· Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.).
CANCER RESEARCH
· Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.).
· Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Tamoxifen
Catalog #
72664, 72662, 72666
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Tamoxifen
Catalog #
72664, 72666
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Resources and Publications
Educational Materials (3)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to Tamoxifen and its salts which is known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov
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