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人重组IL-6

白介素6
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产品号 #78050_C

白介素6

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概述

白细胞介素6 （IL-6）是一种多效生长因子，在免疫调节、造血和肿瘤发生等方面具有广泛的生物活性。IL-6由多种细胞类型产生，包括T细胞、B细胞、单核细胞和巨噬细胞、成纤维细胞、肝细胞、血管内皮细胞和各种肿瘤细胞系。IL-6单独或与其他因子如IL-2和干扰素-γ联合作用时，可刺激B细胞、T细胞和杂交瘤细胞的增殖(Hirano等；Mihara等人；田中等人)。与IL-3、GM-CSF和SCF等细胞因子联合使用，IL-6已被证明能促进体外造血祖细胞增殖和分化。IL-6通过由配体结合IL-6α (CD126)和信号转导gp130亚基组成的细胞表面I型细胞因子受体复合物发出信号。IL-6与其受体系统的结合包括激活JAK/STAT信号通路(Mihara et al.；Peters等人；田中等人)。

Subtype
Cytokines
 
Cell Type
Airway Cells, B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Lymphocytes, Neurons, Pluripotent Stem Cells, T Cells
 
Species
Human
 
Area of Interest
Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
 
Purity
≥ 97%
 

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Data Figures

(A) The biological activity of Human Recombinant IL-6 was tested by its ability to promote the proliferation of B9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 3.31 pg/mL.
(B) 1 μg of Human Recombinant IL-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6 has a predicted molecular mass of 21 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-6
Catalog #
78050, 78050.2, 78050.1
Lot #
1000122298 or higher
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-6
Catalog #
78050, 78050.2, 78050.1
Lot #
1000122297 or lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-6
Catalog #
78050, 78050.2, 78050.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Purity ≥ 97%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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