切换导航
  • 比较产品
我的购物车

小鼠重组IL-21

白介素21
率先评论此产品
添加并比较

产品号 #（选择产品）

产品号 #78116_C

白介素21

main product photo
总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
相关产品

概述

白细胞介素21 （IL-21）是一种多效性细胞因子，由四个α-螺旋束组成，主要由自然杀伤T细胞（NKT）、T滤泡辅助细胞（Tfh）和Th17细胞产生（Spolski & Leonard 2008）。IL-21通过IL-21受体和IL-2受体亚基γ （IL-2RG或CD132）的受体异二聚化传递信号，两者都具有共同的γ链亚基，并激活JAK/STAT， MAPK和PI3K途径(Parrish-Novak等；Ozaki et al. 2000；Spolski & Leonard 2014)。IL-21已被证明在调节免疫球蛋白的产生和促炎Th17细胞群的分化中起关键作用(Ozaki等人，2002；Nurieva等人)。此外，IL-21特异性地维持CD8+ T细胞效应活性，并在慢性病毒感染期间提供CD4+ T细胞帮助的机制（Elsaesser等）。IL-21信号也被发现对非肥胖糖尿病（NOD）小鼠的1型糖尿病的发展至关重要（Sutherland等人），并通过调节性B细胞控制T细胞自身免疫（Yoshizaki等人）。

Subtype
Cytokines
 
Cell Type
Mesenchymal Stem and Progenitor Cells, NK Cells, T Cells, T Cells, CD4+, T Cells, CD8+, T Cells, Other Subsets
 
Species
Mouse
 
Area of Interest
Immunology, Stem Cell Biology
 
Purity
≥ 95%
 

查看更多 显示更少

Data Figures

(A) The biological activity of Mouse Recombinant IL-21 was tested by its ability to promote the proliferation of human ANBL-6 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 1 ng/mL. (B) 2 μg of Mouse Recombinant IL-21 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant IL-21
Catalog #
78116.2, 78116, 78116.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant IL-21
Catalog #
78116.2, 78116, 78116.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (1)

Human Immune Cytokines
Wallchart
Human Immune Cytokines

更多信息

更多信息
Species Mouse
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
版权 © 2025 STEMCELL Technologies 技术有限公司。保留所有权利。