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人重组IL-21

白介素21
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产品号 #78082_C

白介素21

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概述

白细胞介素21 （IL-21）是一种多效性细胞因子，由四个α-螺旋束组成，主要由自然杀伤T细胞（NKT）、T滤泡辅助细胞（Tfh）和Th17细胞产生（Spolski & Leonard 2008）。IL-21信号通过IL-21受体（IL-21R）的异源二聚体和il - 2rg编码的常见细胞因子受体γ链(Parrish-Novak et al.；Ozaki K et al. 2000)，并利用JAK/STAT、MAPK和PI3K通路（Spolski & Leonard 2014）。IL-21已被证明在调节免疫球蛋白的产生和促炎Th17细胞群的分化中起关键作用(Ozaki等人，2002；Nurieva等人)。此外，IL-21特异性地维持CD8+ T细胞效应活性，并在慢性病毒感染期间提供CD4+ T细胞帮助的机制（Elsaesser等）。IL-21信号也被发现对NOD小鼠1型糖尿病的发展至关重要（Sutherland等人），并通过调节性B细胞控制T细胞自身免疫（Yoshizaki等人）。

Subtype
Cytokines
 
Cell Type
Mesenchymal Stem and Progenitor Cells, NK Cells, T Cells, T Cells, CD4+, T Cells, CD8+, T Cells, Other Subsets
 
Species
Human
 
Area of Interest
Immunology, Stem Cell Biology
 
Purity
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant IL-21 was tested by its ability to inhibit the proliferation of Mino cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.5 ng/mL. (B) 2 μg of Human Recombinant IL-21 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-21 has a predicted molecular mass of 15.4 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-21
Catalog #
78082, 78082.2, 78082.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-21
Catalog #
78082, 78082.2, 78082.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Purity ≥ 95 %
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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