产品号 #72146_C
BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6
概述
LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC50 = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.). It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.). This product is supplied as the dihydrochloride hydrate form of the molecule.
DIFFERENTIATION
· Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.).
· Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.).
· Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.).
· Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.).
CANCER RESEARCH
· Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.).
· Prevents ovarian cancer cell proliferation (Tsai et al.).
Alternative Names
DM-3189
Cell Type
Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Neural Cells, PSC-Derived, Pluripotent Stem Cells, Prostate Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Maintenance
Area of Interest
Neuroscience, Stem Cell Biology
CAS Number
1435934-00-1
Chemical Formula
C₂₅H₂₂N₆ · 2HCl [XH2O]
Molecular Weight
479.4 g/mol
Purity
> 98%
Pathway
BMP
Target
ALK1, ALK2, ALK3, ALK6
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
Legal Statement: Sold under license of at least US Patent Nos. 8,507,501 and 9,045,484, and any foreign counterparts thereof. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
