Indomethacin is a non-steroidal, anti-inflammatory agent that inhibits cyclooxygenase (COX) activity, thereby blocking the production of prostaglandins (Vane et al.). Indomethacin inhibits both COX-1 and COX-2 (IC50 = 0.08 and 0.96 µM for recombinant human COX-1 and COX-2, respectively; Kurumbail et al.).
DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).
· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).
CANCER RESEARCH
· Inhibits growth of mouse mammary tumors (Fulton).
· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
DIFFERENTIATION
· Activates peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor known to play a pivotal role in adipogenesis (Lehmann et al.).
· Inhibits chondrogenic differentiation in ATDC5 cells and bone marrow stem cells (Caron et al.).
CANCER RESEARCH
· Inhibits growth of mouse mammary tumors (Fulton).
· Induces apoptosis in prostate and gastric cancer cells (Chiou et al.; Liu et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Indomethacin
Catalog #
73942
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Indomethacin
Catalog #
73942
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Mesenchymal Stem and Progenitor Cell Research
Resources and Publications
Educational Materials (3)
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