IBMX is an inhibitor of cyclic nucleotide phosphodiesterases (PDEs; IC₅₀ = 19, 50, 18, 13, 32, 7, and 50 µM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases.
DIFFERENTIATION
· Used in combination with fibroblast growth factor (FGF) 1, dopamine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and forskolin to induce expression of the dopaminergic neuron marker tyrosine hydroxylase in neurons derived from the human NT2 cell line (Iacovitti et al.).
· Used in combination with dexamethasone, insulin, and indomethacin for in vitro induction of adipogenic differentiation of unrestricted somatic stem cells (USSCs), a CD45-negative population of stem cells isolated from human cord blood (Kögler et al.; Pittenger et al.).
· Induces neural differentiation from human umbilical cord blood-derived mesenchymal stem cells (MSCs; Tio et al.).
· Promotes the differentiation of rat neural progenitor cells (NPCs) into functional neurons in vitro (Lepski et al.).
DIFFERENTIATION
· Used in combination with fibroblast growth factor (FGF) 1, dopamine, 12-O-tetradecanoylphorbol-13-acetate (TPA), and forskolin to induce expression of the dopaminergic neuron marker tyrosine hydroxylase in neurons derived from the human NT2 cell line (Iacovitti et al.).
· Used in combination with dexamethasone, insulin, and indomethacin for in vitro induction of adipogenic differentiation of unrestricted somatic stem cells (USSCs), a CD45-negative population of stem cells isolated from human cord blood (Kögler et al.; Pittenger et al.).
· Induces neural differentiation from human umbilical cord blood-derived mesenchymal stem cells (MSCs; Tio et al.).
· Promotes the differentiation of rat neural progenitor cells (NPCs) into functional neurons in vitro (Lepski et al.).
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Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
IBMX
Catalog #
72764, 72762
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mesenchymal Stem and Progenitor Cell Research
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