产品号 #78202_C
Vascular endothelial growth factor C
概述
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF/platelet-derived growth factor (PDGF) family of proteins. VEGF-C is a potent angiogenic factor and promotes lymphangiogenesis, endothelial cell growth and survival, and can affect blood vessel permeability. VEGF-C is expressed in a range of tissues, but is not expressed in peripheral blood lymphocytes. VEGF-C forms a non-covalent, cell surface-associated, disulfide-linked homodimer that can bind and activate VEGF receptors 2 (VEGFR-2 [Flk1]) and 3 (VEGFR-3 [Flt4]). Interaction with VEGFR-2 results in physiological and intratumoral neoangiogenesis and vessel sprouting (Cao et al.; Tammela et al.), whereas interaction with VEGFR-3 is critical for lymphangiogenesis (Karkkainen et al.; Laakkonen et al.; Mäkinen et al.). Overexpression of VEGF-C in tumor cells has been shown to result in enhanced lymph flow and increased metastasis to regional lymph nodes (Hoshida et al.; Mandriota et al.; Padera et al.; Skobe et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Flt4-L, Flt4 ligand, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, VRP
Cell Type
Endothelial Cells
Species
Human
Area of Interest
Endothelial Cell Biology
Molecular Weight
13.2 kDa
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant VEGF-C was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 500 ng/mL. (B) 2 μg of Human Recombinant VEGF-C was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant VEGF-C has a predicted molecular mass of 13.2 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant VEGF-C Catalog #
78202.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant VEGF-C Catalog #
78202.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for hPSC-Derived Mesoderm Cell Research
Resources and Publications
Educational Materials (4)
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