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重组人VEGF-121

血管内皮生长因子
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产品号 #78127_C

血管内皮生长因子

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总览
实验数据
产品说明书及文档
应用领域
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总览

血管内皮生长因子（VEGF-121）是VEGF-A的一个天然剪接变体，参与胚胎期的血管发生和血管生成。VEGF可与VEGFR-1和VEGFR-2受体结合，并激活Raf/MEK/ERK和PI3K/AKT信号通路。VEGF-121作为一种自由扩散的蛋白形式由多种正常细胞和转化细胞释放。它在体外和体内的神经发生中都起着重要作用（Storkebaum 等人）。它对中枢神经系统的神经元有神经营养作用，促进多巴胺能神经元和星形胶质细胞的生长和存活。此外，VEGF还促进血管内皮细胞的生长和存活，诱导单核细胞趋化，以及粒-巨噬细胞祖细胞的集落形成（Ferrara等人）。

亚型
细胞因子，生长因子
 
细胞类型
血管生成细胞，内皮细胞，造血干/祖细胞，间充质干/祖细胞，中胚层，PSC衍生，神经干/祖细胞，多能干细胞
 
种属
人
 
研究领域
血管生成细胞研究，内皮细胞研究，神经科学，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant VEGF-121 was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 4.02 ng/mL. (B) 1 μg of Human Recombinant VEGF-121 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant VEGF-121
Catalog #
78127.2, 78127, 78127.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant VEGF-121
Catalog #
78127.2, 78127, 78127.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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