产品号 #78125_C
Tumor necrosis factor beta
概述
Tumor necrosis factor-beta (TNF-β), also known as lymphotoxin-alpha, is a member of the TNF family. It is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways upon binding to TNF receptors 1 and 2. It is produced mainly by T cells, though other cells can express TNF-β at lower levels (Chu). TNF-β is involved in autoimmune disorders, lymph node development, and mediating the inflammatory demyelination process (Seleznik et al.; McCarthy et al.).
Subtype
Cytokines
Cell Type
T Cells
Species
Human
Area of Interest
Immunology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant TNF-beta was tested by its ability to inhibit growth of mouse L929 cells growing in the presence of actinomycin D. Cell growth was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.004 ng/mL. (B) 2 μg of Human Recombinant TNF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant TNF-beta Catalog #
78125.1, 78125 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant TNF-beta Catalog #
78125.1, 78125 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Workflow Stages
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