产品号 #78169_C
Platelet factor 4
概述
Platelet factor 4 (PF-4), or CXCL4, is a member of the CXC chemokine family. It is produced by megakaryocytes, platelets, and cultured microglial cells (Kasper & Petersen; Wang & Huang). Although its receptors have not been fully characterized, PF-4 appears to affect p38/MAPK, PI3K/AKT, ERK, and JNK/c-Jun signaling pathways. PF-4 inhibits the development and maturation of megakaryocytes, and supports survival of hematopoietic stem and progenitor cells (Kasper & Petersen). PF-4 inhibits angiogenesis by suppressing endothelial cell proliferation and migration. It promotes inflammatory response through activation of granulocytes, T cells, and monocytes, which results in the release of oxygen radicals and cytokines, and induces phagocytosis. PF-4 stimulates NK cell migration, inhibits platelet coagulation, and together with TNF, PF-4 causes neutrophile degranulation (Kasper & Petersen; Wang & Huang).
Subtype
Cytokines
Alternative Names
CXCL4, Ironplact, Oncostatin A, Platelet factor-4, SCYB4
Cell Type
Hematopoietic Stem and Progenitor Cells, Monocytes
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
7.8 kDa
Purity
≥ 95%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant PF-4 (CXCL4) Catalog #
78169.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant PF-4 (CXCL4) Catalog #
78169.1 Lot #
All Language
English Resources and Publications
Educational Materials (5)
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