产品号 #78087_C
Monocyte chemotactic protein 1
概述
Monocyte chemotactic protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. The protein is primarily induced by platelet-derived growth factor (PDGF) gene (Cochran et al.). The biological effects of MCP-1 are mediated via the specific G-protein-coupled receptor CCR2 which in turn activates signal transduction pathways leading to monocyte transmigration (Sozzani et al.). Migration of monocytes from the bloodstream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as other immunomodulatory effects. MCP-1 is produced by a variety of cell types, including fibroblasts and endothelial, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells, which are important for antiviral responses in the peripheral circulations and in tissues (Cushing et al.; Deshmane et al.). MCP-1 plays a role in physiological processes such as neurogenesis, neuroprotection, and neurotransmission and has important implications in neurological disorders such as multiple sclerosis and Alzheimer’s disease, in which it is produced during neuroinflammation at the sites of lesions (Conductier et al.).
Subtype
Cytokines
Cell Type
Macrophages, Monocytes, Myeloid Cells, NK Cells, T Cells
Species
Human
Area of Interest
Immunology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant MCP-1 was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 1 hour using a fluorometric assay method. Increase in migration over basal level was seen starting at 1 ng/mL. (B) 1 μg of Human Recombinant MCP-1 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant MCP-1 has a predicted molecular mass of 8.7 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant MCP-1 (CCL2) Catalog #
78087.1, 78087 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant MCP-1 (CCL2) Catalog #
78087.1, 78087 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Granulocyte Research
Workflow Stages for Monocyte Research
Resources and Publications
Educational Materials (3)
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