产品号 #78083_C
Interleukin 6 receptor alpha
概述
Interleukin 6 receptor (IL-6R) alpha is a type I transmembrane glycoprotein that forms a complex with type I transmembrane signal transducer protein gp130 (CD130) and mediates the biological activities of IL-6. IL-6 binds to the membrane-bound non-signaling IL-6R alpha (mIL-6R), and the complex binds to two molecules of gp130 and leads to ‘classical’ IL-6-signal transduction, which includes activation of JAK/STAT, ERK, and PI3K signal transduction pathways (Scheller et al.). In contrast, a soluble form of IL-6R alpha (sIL-6R), which comprises the extracellular portion of the receptor, binds to the secreted IL-6 to form a complex that promotes bioavailability of IL-6. The complex of IL-6 and sIL-6R can bind to gp130 on cells that do not express the IL-6R and are unresponsive to IL-6. This process is known as trans-signaling (Hunter & Jones; Rose-John S). sIL-6R regulates both local and systemic IL-6-mediated events. Elevated levels of sIL-6R have been documented in several disease conditions such as rheumatoid arthritis, myeloma, and Crohn’s disease (Jones et al.; Mihara et al.).
Subtype
Cytokines
Alternative Names
B cell stimulatory factor-2, CD126, IL-6R, IL-6R1, IL-6RA, Interleukin-6 receptor, Interleukin-6 receptor alpha
Cell Type
Dendritic Cells, Epithelial Cells, Hematopoietic Stem and Progenitor Cells, Lymphocytes, Mesoderm, PSC-Derived
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
50 - 58 kDa
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant IL-6R alpha was tested by its ability to inhibit the proliferation of M1 cells. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is less than 200 ng/mL. (B) 5 μg of Human Recombinant IL-6R alpha was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6R alpha has a predicted molecular mass of 50 - 58 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant IL-6R alpha Catalog #
78083.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IL-6R alpha Catalog #
78083.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Airway Epithelial Cell Research
Workflow Stages for Dendritic Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for hPSC-Derived Mesoderm Cell Research
Workflow Stages for Intestinal Epithelial Cell Research
Workflow Stages for Total Lymphocyte Research
Resources and Publications
Educational Materials (4)
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