产品号 #78216_C
Interleukin 31
概述
Interleukin 31 (IL-31), a four-helix bundle inflammatory cytokine, belongs to the IL-6 cytokine family which includes IL-6 (Catalog #78050), oncostatin M (Catalog #78094), leukemia inhibitory factor (LIF; Catalog #78055), and cardiotrophin-1 (Catalog #78160; Dillon et al.). IL-31 signals through a heterodimer composed of IL-31RA (also known as gp130-like receptor or GPL) and the oncostatin-M receptor (OSMR), both of which are expressed on monocytes (Diveu et al.; Ghilardi et al.), epithelial cells (Ip et al.), and keratinocytes (Kato et al.). Signaling through the GPL/OSMR complex activates the JAK/STAT, RAS/ERK, and PI3K/AKT signaling pathways, resulting in the downstream activation of STAT1, STAT3, and STAT5 transcription factors (Cornelissen et al.; Dambacher et al.; Dillon et al.; Ip et al.). IL-31 responses have been associated with allergic responses and inflammatory skin diseases including atopic dermatitis (Cornelissen et al.; Gangemi et al.).
Subtype
Cytokines
Cell Type
Dendritic Cells, Intestinal Cells, Macrophages, Monocytes, T Cells
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant IL-31 was tested by STAT3 activation in U-87 MG cells. The detection limit was ≤ 25 ng/mL. (B) Human Recombinant IL-31 was resolved with SDS-PAGE under reducing (+) conditions and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-31 has a predicted molecular mass of 15.8 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant IL-31 Catalog #
78216.3, 78216.1, 78216 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IL-31 Catalog #
78216.3, 78216.1, 78216 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Dendritic Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Intestinal Epithelial Cell Research
Workflow Stages for Monocyte Research
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