产品号 #78023_C
Insulin-like growth factor 2
概述
Insulin-like growth factor 2 (IGF-II) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-II binding to IGF-I receptor activates a signaling cascade via the MAPK and PI3K pathways. IGF-II affects growth, differentiation, and survival of cells in a variety of tissues during embryonic development. It stimulates proliferation and migration of primary lymphatic endothelial cells, and induces lymphangiogenesis (Guvakova).
Subtype
Cytokines, Growth Factors
Alternative Names
<p>Insulin-like growth factor II, Insulin-like growth factor type 2, Somatomedin A, T3M-11-derived growth factor<br></p>
Cell Type
Hematopoietic Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Purity
≥ 95%
Data Figures
Figure 1. Biological Activity and Molecular Weight of Human Recombinant IGF-II, ACF
(A) The biological activity of Human Recombinant IGF-II was tested by its ability to promote the proliferation of MCF-7 cells. The EC50 is defined as the effective concentration of the cytokines at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 6 ng/mL. (B) 1 μg of Human Recombinant IGF-II was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-II has a predicted molecular mass of 7.5 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1 Product Name
Human Recombinant IGF-II Catalog #
78023.2, 78023.1, 78023 Lot #
1000145724 and higher Language
English Document Type
Product Information Sheet 2 Product Name
Human Recombinant IGF-II Catalog #
78023.2, 78023.1, 78023 Lot #
1000145723 and lower Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IGF-II Catalog #
78023.2, 78023.1, 78023 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Resources and Publications
Educational Materials (1)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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