产品号 #78142_C
Insulin-like growth factor 1, animal component-free
概述
Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.). This product is animal component-free.
Subtype
Cytokines, Growth Factors
Alternative Names
<p>IBP1, IGF-IA, IGF-IB, IGF1A, Insulin-like growth factor 1, Mechano growth factor, MGF, Somatomedin C<br></p>
Cell Type
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Formulation Category
Animal Component-Free
Purity
≥ 95%
Data Figures
Figure 1. Biological Activity and Molecular Weight of Human Recombinant IGF-I, ACF
(A) The biological activity of Human Recombinant IGF-I, ACF was tested by its ability to promote the proliferation of MCF-7 cells. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is ≤ 1.5 ng/mL. (B) 1 μg of Human Recombinant IGF-I, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1 Product Name
Human Recombinant IGF-I, ACF Catalog #
78142.1, 78142, 78142.2 Lot #
1000172765 and lower Language
English Document Type
Product Information Sheet 2 Product Name
Human Recombinant IGF-I, ACF Catalog #
78142.1, 78142, 78142.2 Lot #
1000172766 and higher Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IGF-I, ACF Catalog #
78142.1, 78142, 78142.2 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Human Pluripotent Stem Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for hPSC-Derived Endoderm Cell Research
Resources and Publications
Educational Materials (2)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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