产品号 #78077_C
Interferon-alpha 2B
概述
Interferon-alpha (IFN-α) is a type I interferon, produced by virus infected cells, and is released as a soluble factor to initiate antiviral responses (Isaacs & Lindenmann). IFN-α2 is the most potent IFN-α used in fundamental research and in most clinical applications. The best known IFN-α2 subvariants, 2A and 2B, differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (von Gabain et al.). Type I IFNs exert potent antitumor activity by increasing the cytotoxic activity of NK and T cells, as well as inhibiting the proliferation of cancer cells (Paul et al.). Additionally, it has been shown that proinflammatory IFN-α modulates the function of B cells in patients with systemic lupus erythematosus (Chang et al.) and pegylated form of IFN-α 2A and 2B has implications in the treatment of Hepatitis C (Foster et al.).
Subtype
Cytokines
Cell Type
B Cells, Cancer Cells and Cell Lines, NK Cells, T Cells
Species
Human
Area of Interest
Cancer, Immunology
Purity
≥ 95 %
Data Figures
(A) The biological activity of Human Recombinant IFN-alpha 2B was measured with A549 cells exposed to the encephalomyocarditis (EMC) virus in a cytopathic effect (CPE) assay. Cell survival was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell survival is at 50% of maximum. The EC50 in the example above is 1.0 pg/mL. (B) 1 μg of Human Recombinant IFN-alpha 2B was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IFN-alpha 2B has a predicted molecular mass of 19.4 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant IFN-alpha 2B Catalog #
78077.1, 78077 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IFN-alpha 2B Catalog #
78077.1, 78077 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Mammary Epithelial Cell Research
Workflow Stages for Natural Killer Cell Research
Resources and Publications
Educational Materials (3)
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