产品号 #78019_C
Hepatocyte growth factor
概述
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic growth factor that promotes proliferation, motility, survival, and differentiation. HGF binds and promotes the dimerization and activation of the receptor tyrosine kinase c-MET, and stimulates PI3K/AKT, FAK, JNK, and ERK1/2 signaling (Organ & Tsao). HGF stimulates migration of cells during embryogenesis, induces cell motility and scattering of epithelial cells, and regulates epithelial-mesenchymal transition. It is a chemoattractant for motor neurons, and regulates the development of sensory, sympathetic, parasympathetic, and cortical neurons as well as the proliferation of oligodendrocytes and glial development. Additionally, HGF is cytoprotective and regulates liver growth and regeneration (Nakamura et al.).
Subtype
Cytokines, Growth Factors
Cell Type
Airway Cells, Hepatic Cells, Intestinal Cells, Mammary Cells, Neurons, Pluripotent Stem Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant HGF was tested by its ability to promote the proliferation of 4MBr5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 7.2 ng/mL.
(B) 5 μg of Human Recombinant HGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HGF has a predicted molecular mass of 88 - 90 kDa (single chain), 59 - 61 kDa (alpha chain), or 30 - 34 kDa (beta chain).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant HGF (CHO-expressed) Catalog #
78019, 78019.1, 78019.2 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant HGF (CHO-expressed) Catalog #
78019, 78019.1, 78019.2 Lot #
All Language
English Resources and Publications
Educational Materials (1)
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