产品号 #78111_C
生长分化因子5
概述
生长分化因子5 （GDF-5）是转化生长因子β (TGF-β)超家族骨形态发生蛋白（BMP）亚类的成员。它结合一个由BMPR1B和BMPR2组成的受体复合物，然后激活SMAD信号通路(Carreira等人；西藤等人；Osório等)。GDF-5在发育过程中促进间充质干细胞的软骨分化、骨骼形成和树突生长(Coleman等；Francis-West等人)。对大鼠的研究表明，GDF-5调节模式、神经发生、星形胶质发生和神经元规格(Gajavelli等人；Krieglstein等人；O’keeffe等人)。
Subtype
Cytokines
Alternative Names
BMP-14, Bone morphogenic protein 14, CDMP-1, Growth differentiation factor 5
Cell Type
Endoderm, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
13.7 kDa monomer; 27.4 kDa dimer
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (4)
更多信息
| Molecular Weight | 13.7 kDa monomer; 27.4 kDa dimer |
|---|---|
| Species | Human |
| Alternative Names | BMP-14, Bone morphogenic protein 14, CDMP-1, Growth differentiation factor 5 |
| Purity | ≥ 95% |
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
