产品号 #100-1718_C
Granulocyte colony-stimulating factor, Fc tag
概述
Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf & Nicola. J Cell Physiol, 1983). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit et al. Nat Immunol, 2002), the activation of metalloproteases that cleave VCAM-1 (Levesque et al. Blood, 2001), and the release of norepinephrine from the sympathetic nervous system (Katayama et al. Cell, 2006), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways. At the carboxy terminus, Human Recombinant G-CSF (HEK293-expressed) contains a human IgG1 Fc tag.
Subtype
Cytokines
Alternative Names
Colony-stimulating factor 3, CSF-3, MGI-1G, Pluripoietin
Cell Type
Cancer Cells and Cell Lines, Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Neurons
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Purity
≥ 94%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (8)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
