产品号 #78187_C
Fibroblast growth factor-acidic
概述
Fibroblast growth factor acidic (FGF-acidic), also known as FGF-1, is a potent activator of DNA synthesis, cell proliferation, and chemotaxis and is known to play numerous roles in development, regeneration, and angiogenesis (Jaye et al.; Galzie et al.; Presta et al.). FGF-acidic is produced by multiple cell types and is capable of activating all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It is found in large quantities in the brain, but is also expressed in hepatocytes, vascular smooth muscle cells, neurons of the CNS, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF-acidic is secreted as a disulfide-linked homodimer and is stored in complex with heparan sulfate, a requirement for its interaction with FGF receptors (Guerrini et al.; Mohammadi et al.). Internalized FGF-acidic signals through protein kinase C and promotes cell survival by inhibiting p53 and proapoptotic signaling (Bouleau et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Acidic fibroblast growth factor, aFGF, ECGF, Endothelial cell growth factor, FGF-1, FGF-alpha, Fibroblast growth factor 1, GLIO703, HBGF-1, Heparin-binding growth factor 1
Cell Type
Endoderm, PSC-Derived, Endothelial Cells, Epithelial Cells, Fibroblasts, Granulocytes and Subsets, Keratinocytes, Mesoderm, PSC-Derived, Neurons, Smooth Muscle
Species
Human
Area of Interest
Immunology, Neuroscience, Stem Cell Biology
Molecular Weight
15.8 kDa
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (5)
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
