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重组人酸性成纤维细胞生长因子 (FGF-acidic)

酸性成纤维细胞生长因子
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产品号 #78187_C

酸性成纤维细胞生长因子

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总览

重组人酸性成纤维细胞生长因子 (FGF-acidic)，也称为 FGF-1，是 DNA 合成、细胞增殖和趋化作用的强效激活剂，已知在发育、再生和血管生成中发挥多种作用 (Jaye et al.; Galzie et al.; Presta et al.)。FGF-acidic 由多种细胞类型产生，能够激活所有中胚层来源的细胞以及许多神经外胚层、外胚层和内胚层来源的细胞。它在脑中大量存在，但也在肝细胞、血管平滑肌细胞、中枢神经系统神经元、骨骼肌细胞、成纤维细胞、角质形成细胞、内皮细胞、肠柱状上皮细胞以及垂体嗜碱性粒细胞和嗜酸性粒细胞中表达。 FGF-acidic 以二硫键连接的同型二聚体形式分泌，并与硫酸乙酰肝素形成复合物储存，这是其与 FGF 受体相互作用的必要条件 (Guerrini et al.; Mohammadi et al.)。内化的 FGF-acidic 通过蛋白激酶 C 发出信号，并通过抑制 p53 和促凋亡信号来促进细胞存活 (Bouleau et al.)。

亚型
细胞因子，生长因子
 
别名
酸性成纤维生长因子；aFGF；ECGF；内皮细胞生长因子；FGF-1；FGF-alpha；成纤维生长因子 1；GLIO703；HBGF-1；肝素结合生长因子 1
 
细胞类型
内胚层，PSC衍生，内皮细胞，上皮细胞，成纤维细胞，粒细胞及其亚群，角质形成细胞，中胚层，PSC衍生，神经元，平滑肌
 
种属
人
 
研究领域
免疫，神经科学，干细胞生物学
 
分子量
15.8 千道尔顿
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant FGF-acidic was tested by its ability to promote the proliferation of BALB/c 3T3 cells in the presence of 10 μg/mL heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.3 ng/mL. (B) 2 μg of Human Recombinant FGF-acidic was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-acidic has a predicted molecular mass of 15.8 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant FGF-acidic
Catalog #
78187.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant FGF-acidic
Catalog #
78187.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

更多信息

更多信息
Molecular Weight 15.8 kDa
Species Human
Alternative Names Acidic fibroblast growth factor, aFGF, ECGF, Endothelial cell growth factor, FGF-1, FGF-alpha, Fibroblast growth factor 1, GLIO703, HBGF-1, Heparin-binding growth factor 1
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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