重组人FGF-9

成纤维细胞生长因子9

产品号 #(选择产品)

产品号 #78161_C

成纤维细胞生长因子9

总览

成纤维细胞生长因子(FGF) 9是FGF家族中一个多效性成员。FGF是肝素依赖性的细胞增殖和分化调节因子(Itoh & Ornitz)。FGF-9通过结合FGFR3(IIIb)以及FGFR1、FGFR2和FGFR3受体的 IIIc 剪接变体来传递信号(Santos-Ocampo等;Mohammadi等;Plotnikov等)。在小鼠中,FGF-9的缺失会导致死亡,FGF-9的表达影响骨骼、小脑、肺、心脏、血管系统、消化道和睾丸的发育(Colvin等;Harada等;Lin等)。据报道,在多种人类癌症中FGF-9水平也会发生变化(Leushacke等;Abdel-Rahman等)。

亚型
细胞因子,生长因子
 
别名
成纤维生长因子-9;GAF;胶质激活因子;HBGF-9
 
细胞类型
气道细胞,间充质细胞,PSC衍生,间充质干/祖细胞
 
种属

 
研究领域
神经科学,类器官,呼吸系统研究,干细胞生物学
 
分子量
23.4 千道尔顿
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant FGF-9 was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 2 ng/mL. (B) 2 μg of Human Recombinant FGF-9 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-9 has a predicted molecular mass of 23.4 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78161.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78161.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Molecular Weight 23.4 kDa
Species Human
Alternative Names Fibroblast growth factor-9, GAF, Glia-activating factor, HBGF-9
Purity ≥ 95%
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