产品号 #78008_C
Fibroblast growth factor 8B
概述
Fibroblast growth factor 8B (FGF-8B) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and are involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8B signals through FGF receptors (FGFRs) to activate PI3K and MAPK pathways. FGF-8B is broadly associated with mitogenic and cell survival activities, and regulates gastrulation, epithelial-mesenchymal transition, and later on mesenchymal to epithelial differentiation during embryonic development. FGF-8B has also been found in peripheral blood leukocytes and healthy bone marrow samples (Mattila & Härkönen). FGF-8B has mitogenic effects on somatic cells in the germinal epithelium and is expressed in adult mouse ovarian cells and tissues, which suggests that it regulates maturation of oocytes and seminiferous epithelium in testis (Valve et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
AIGF, Androgen-induced growth factor, FGF-8, FGF-8B, Fibroblast growth factor-8B, HBGF-8, Heparin-binding growth factor 8; HH6, KAL6
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Neural Cells, PSC-Derived, Pluripotent Stem Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
22.5 kDa
Purity
> 95%
Data Figures
(A) The biological activity of Human Recombinant FGF-8B was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 1.8 ng/mL.
(B) 2 μg of Human Recombinant FGF-8B was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-8B has a predicted molecular mass of 22.5 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant FGF-8B Catalog #
78008.2, 78008.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant FGF-8B Catalog #
78008.2, 78008.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Resources and Publications
Educational Materials (1)
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