产品号 #78128_C
Fibroblast growth factor 8A
概述
Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand & Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman & Klagsbrun; Kimelman & Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman & Klagsbrun; Klagsbrun; Rifkin & Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe & Crump; Hulstrand & Houston).
Subtype
Cytokines, Growth Factors
Cell Type
Endoderm, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
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Resources and Publications
Educational Materials (8)
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
