产品号 #78175_C
Fibroblast growth factor 16
概述
Fibroblast growth factor 16 (FGF-16) is a heparin-binding member of the FGF family. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGFs act primarily on cells of mesodermal and neuroectodermal origin to regulate diverse physiological functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, and tissue repair (Goldfarb; Green et al.). In vitro, FGF-16 has been shown to promote the proliferation of brown adipocytes and in rat embryos it is predominantly expressed in these cells. FGF-16 has also been shown to play a critical role in embryonic heart development and is thought to play a cardioprotective role after birth (Hotta et al.; Lu et al.; Wang et al.).
Subtype
Cytokines, Growth Factors
Cell Type
Adipocytes
Species
Human
Area of Interest
Stem Cell Biology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant FGF-16 was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 20 ng/mL. (B) 2 μg of Human Recombinant FGF-16 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-16 has a predicted molecular mass of 23.6 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant FGF-16 Catalog #
78175, 78175.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant FGF-16 Catalog #
78175, 78175.1 Lot #
All Language
English Applications
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Resources and Publications
Educational Materials (5)
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