产品号 #78046_C
成纤维细胞生长因子7
成纤维细胞生长因子 7 (FGF-7) 是 FGF 家族的成员,其作用机制主要通过主要由上皮细胞表达的 FGF 受体亚型发挥作用 (Finch & Rubin)。FGF-7 似乎特异性地作用于上皮细胞,并刺激这些细胞的增殖、迁移和分化,并且还参与体内和体外上皮的保护和修复 (Finch & Rubin; Werner)。相反,FGF-7 仅由间充质细胞产生,并作为间充质-上皮通讯的旁分泌介质发挥作用 (Rubin et al.)。FGF-7 还被证实可以补充生物工程皮肤的多种伤口愈合特性 (Erdag et al.),并诱导人角质形成细胞的自噬 (Belleudi et al.)。此外,FGF-7 在多能干细胞分化为内胚层胰腺样胰岛素分泌细胞和胸腺上皮细胞中发挥作用(Inami et al.; Niu et al.)。
亚型
细胞因子,生长因子
细胞类型
内胚层,PSC衍生,造血干/祖细胞,角质形成细胞,乳腺细胞,间充质干/祖细胞,神经细胞,PSC衍生,神经干/祖细胞,多能干细胞,前列腺细胞
种属
人
研究领域
上皮细胞研究,神经科学,干细胞生物学
纯度
≥ 97 %
(A) The biological activity of Human Recombinant FGF-7 (KGF) was tested by its ability to promote the proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 2 ng/mL. (B) 2 μg of Human Recombinant FGF-7 (KGF) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-7 (KGF) has a predicted molecular mass of 19 kDa.
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Thank you for your interest in IntestiCult™ Organoid Growth Medium (Human). Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
Species | Human |
---|---|
Purity | ≥ 97% |
Defined animal component-free medium for the differentiation of human ES and iPS cells to definitive endoderm
用于培养人乳腺上皮细胞
成分明确、无血清、无异种成分的多能干细胞培养基
碱性成纤维细胞生长因子
扫描二维码或搜索微信号STEMCELLTech,即可关注我们的微信平台,第一时间接收丰富的技术资源和最新的活动信息。
如您有任何问题,欢迎发消息给STEMCELLTech微信公众平台,或与我们通过电话/邮件联系:400 885 9050 INFO.CN@STEMCELL.COM。