产品号 #100-1330_C
Complement factor D, His tag
概述
Complement factor D is a component of the alternative pathway of the complement system and part of the innate immune system, playing a vital role in the initiation and amplification of complement activation, in order to defend against infection (Barratt and Weitz). A serine protease belonging to the S1 peptidase family, complement factor D is secreted by adipocytes into circulating blood, and is also expressed by macrophages and monocytes (White et al.). In the initiation phase of the complement pathway, complement factor D cleaves complement factor B (bound to component C3) to produce a complex known as C3 convertase. During the amplification phase, complement factor D cleaves complement factor B (bound to component C3b) to produce the C3bBb convertase, and is involved in the propagation of complement activation. In addition to its immunological role, complement factor D is involved in other physiological processes, such as the efficient clearing of damaged cell debris by phagocytes following acute liver injury (Cresci et al.). Complement factor D deficiency is associated with an increased susceptibility to pathogens like Neisseria meningitidis (Biesma et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, complement factor D from STEMCELL comes lyophilized with ≥ 94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤ 1.0 EU/μg protein.
Subtype
Cytokines
Alternative Names
Adipsin, ADN, DF, Factor D protein, PFD
Species
Human
Area of Interest
Metabolism
Purity
≥ 94%
Data Figures
Human Recombinant Complement Factor D was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant Complement Factor D has a predicted molecular mass of 25.8 kDa and an apparent molecular mass of 33 kDa due to glycosylation.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant Complement Factor D Catalog #
100-1330 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant Complement Factor D Catalog #
100-1330 Lot #
All Language
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