产品号 #78105_C
翻译:Betacellulin
概述
Betacellulin是表皮生长因子（EGF）家族的一员，通过EGF受体和ERBB4发出信号。它激活ERK和AKT通路，诱导神经干细胞增殖，阻止培养中的自发分化。β细胞素刺激神经干细胞、转运扩增细胞和源自心室下区和齿状回的神经母细胞的扩张（Gómez-Gaviro等）。它是视网膜色素上皮细胞和血管平滑肌细胞的有效丝裂原。Betacellulin通过MEK/ERK1/2和PI3K/AKT信号通路下调卵巢癌细胞系中E-cadherin的表达，从而增加细胞迁移（Zhao等）。它是干扰素（IFN）反应的调节剂，并增强IFN的抗病毒作用（al - yahya等）。β细胞蛋白在胰腺α细胞、β细胞和导管细胞中表达。它可以诱导胰腺癌细胞系的增殖，抑制细胞凋亡，促进β细胞的新生，并将非β细胞转化为产生胰岛素的细胞(Kawaguchi等；Miyagawa。;Saito等人)。
Subtype
Cytokines
Cell Type
Endoderm, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human
Area of Interest
Neuroscience, Stem Cell Biology
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
更多信息
| Species | Human |
|---|---|
| Purity | ≥ 95% |
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
