产品号 #78002_C
B cell activating factor
概述
B cell activating factor (BAFF) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils (Mackay & Browning; Scapini et al.). It binds to 3 receptors: BAFF-R, TACI, and BCMA, all of which are expressed by B cells at various times in their development (Liu & Davidson). BAFF-R signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation (Bossen & Schneider; Liu & Davidson; Naradikian et al.). BAFF also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages (Chang et al.), and co-stimulates anti-CD3-mediated activation of human T cells (Huard et al.; Mackay & Leung).
Subtype
Cytokines
Alternative Names
BLyS, TALL1, TNFSF13B
Cell Type
B Cells
Species
Human
Area of Interest
Immunology
Molecular Weight
17 kDa
Purity
> 95%
Data Figures
(A) The biological activity of Human Recombinant BAFF was tested by its ability to promote mitosis of RPMI-8226 cells. Mitogenic activity was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which mitogenic activity is at 50% of maximum. The EC50 in the above example is less than 20 ng/mL.
(B) 1 μg of Human Recombinant BAFF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions visualized by Coomassie Blue staining. Human Recombinant BAFF has a predicted molecular mass of 17 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant BAFF Catalog #
78002.1, 78002.2 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant BAFF Catalog #
78002.1, 78002.2 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Total Lymphocyte Research
Resources and Publications
Educational Materials (2)
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