产品号 #100-1329_C
15-Hydroxyprostaglandin dehydrogenase, His tag
概述
Modulate prostaglandin metabolism with 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH catalyzes the reversible oxidation of the 15-hydroxyl group in prostaglandins, resulting in inactivated metabolites (Ensor and Tai), it can act on a variety of prostaglandins as substrates in a NAD+ dependent manner (Cho et al.). As prostaglandins can have a range of effects on cellular processes, 15-PGDH is of considerable importance in drug development. In vitro and in vivo studies suggest 15-PGDH has tumor suppressive activity and is downregulated in certain cancers (Na et al.).15-PGDH belongs to the short-chain dehydrogenases/reductases (SDR) family; its primary structure indicates 20% homology with other SDRs, with some conserved amino acid residues (Krook et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apo M from STEMCELL comes lyophilized with ≥ 89% purity.
Subtype
Cytokines
Alternative Names
PGDH, PGDH1, PHOAR1, SDR36C1
Species
Human
Area of Interest
Metabolism
Purity
≥ 89%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant 15-PGDH Catalog #
100-1329 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant 15-PGDH Catalog #
100-1329 Lot #
All Language
English Request Pricing
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