产品号 #70023_C
冻存的人原代细胞
通过免疫磁珠负选从单核细胞（MNC）中分离人外周血原代B细胞（PB）。细胞未被标记，可立即用于下游应用。PB采集过程中添加酸-柠檬酸-葡萄糖溶液A作为抗凝剂（ACDA）。
细胞采集均通过机构审查委员会（IRB）批准的知情同意书及方案进行。
某些产品仅在特定地区出售。请与您当地的销售代表或产品与科学支持联系techsupport@stemcell.com获取更多信息。
欲了解更多信息，请浏览有关原代细胞的常见问题解答（FAQs）。
细胞采集均通过机构审查委员会（IRB）批准的知情同意书及方案进行。
某些产品仅在特定地区出售。请与您当地的销售代表或产品与科学支持联系techsupport@stemcell.com获取更多信息。
欲了解更多信息，请浏览有关原代细胞的常见问题解答（FAQs）。
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (4)
Publications (1)
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. Journal of medicinal chemistry 2014 MAY
Abstract
Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indications, but its clinical progress has been hampered by dose-limiting adverse effects that have been attributed, at least in part, to the off-target activities of 1. It is expected that a more selective Syk inhibitor would provide a greater therapeutic window. Herein we report the discovery and optimization of a novel series of imidazo[1,2-a]pyrazine Syk inhibitors. This work culminated in the identification of GS-9973, 68, a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.
更多信息
| Species | Human |
|---|---|
| Contains | • CryoStor® CS10 |
| Purity | ≥ 85% CD19+ by flow cytometry |
| Cell And Tissue Source | Peripheral Blood |
| Donor Status | Normal |
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