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抗人CD19抗体，克隆HIB19

抗人、黑猩猩CD19的小鼠单克隆IgG1抗体
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产品号 #60005_C

抗人、黑猩猩CD19的小鼠单克隆IgG1抗体

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总览
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总览

HIB19抗体靶向CD19，这是一种约95 kDa的I型跨膜糖蛋白，在所有发育阶段的B细胞表面均有表达（从前B细胞到浆细胞）。其表达量在终末分化的浆细胞中下调但仍持续存在。CD19也表达于滤泡树突状细胞。通过与CD21和CD81形成复合物，CD19作为B细胞受体的共受体参与B细胞活化与分化。CD19的激活伴随其胞内域磷酸化，进而招募激酶并诱导下游信号通路。CD19基因突变可导致严重免疫缺陷综合征。

该抗体克隆已通过验证，适用于以下EasySep™分选试剂盒分离细胞的纯度检测，包括EasySep™人CD19正选试剂盒（产品号 #18054）、EasySep™ 人全血CD19正选试剂盒（产品号 #18084）、EasySep™ HLA 全血B细胞正选试剂盒（产品号 #18184HLA）；可能会观察到部分阻断，以及 EasySep™ HLA B 细胞富集：用于处理全血的完全试剂盒（产品号 #19954HLA）和 EasySep™ HLA 总淋巴细胞富集：用于处理全血的完全试剂盒（产品号 #19961HLA）。

亚型
一抗
 
靶抗原
CD19
 
别名
B4
 
活性物种
Chimpanzee，人
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，PE，PerCP-Cyanine5.5，未偶联的
 
宿主物种
小鼠
 
细胞类型
B 细胞
 
种属
人，非人灵长类
 
应用
细胞分选，CyTOF，流式细胞术，功能学筛选，免疫组化
 
研究领域
免疫
 
克隆
HIB19
 
基因编号
930
 
同种型
IgG1，kappa
 

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Data Figures

Data for Alexa Fluor® 488-Conjugated

Figure 1. Data for Alexa Fluor® 488-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, Alexa Fluor® 488 and anti-human CD45 APC.
(B) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, Alexa Fluor® 488. Histograms show labeling of the PBMCs (Start) and isolated cells (Isolated). Labeling with a mouse IgG1, kappa Alexa Fluor® 488 isotype control antibody is shown in the bottom panel (open histogram).

Data for APC-Conjugated

Figure 2. Data for APC-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, APC (filled histogram) or a mouse IgG1, kappa APC isotype control antibody (black line histogram).
(B) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, APC. Histograms show labeling of PBMCs (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa APC isotype control antibody is shown (open histogram).
(C) Flow cytometry analysis of human whole blood nucleated cells processed with the EasySep™ HLA B Cell Enrichment: Complete Processing Kit for Whole Blood and labeled with Anti-Human CD19 Antibody, Clone HIB19, APC. Histograms show labeling of HetaSep™-treated whole blood cells (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa APC isotype control antibody is shown (open histogram).

Data for Biotin-Conjugated

Figure 3. Data for Biotin-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, Biotin followed by streptavidin (SAV) APC (filled histogram) or a mouse IgG1, kappa biotin isotype control antibody followed by SAV APC (black line histogram).
(B) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, Biotin followed by streptavidin (SAV) APC. Histograms show labeling of PBMCs (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa biotin isotype control antibody followed by SAV APC is shown (open histogram).
(C) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ HLA Whole Blood B Cell Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, Biotin followed by streptavidin (SAV) APC. Histograms show labeling of buffy coat nucleated cells (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa biotin isotype control antibody followed by SAV APC is shown (open histogram).

Data for FITC-Conjugated

Figure 4. Data for FITC-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, FITC (filled histogram) or a mouse IgG1, kappa FITC isotype control antibody (black line histogram).
(B) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, FITC. Histograms show labeling of PBMCs (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa FITC isotype control antibody is shown (open histogram).
(C) Flow cytometry analysis of human buffy coat nucleated cells processed with the EasySep™ Human Whole Blood CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, FITC. Histograms show labeling of buffy coat nucleated cells (Start) and isolated cells (Isolated). Labeling of start cells with a mouse IgG1, kappa FITC isotype control antibody is shown (open histogram).

Data for PE-Conjugated

Figure 5. Data for PE-Conjugated

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, PE and antihuman CD45 APC.
(B) Flow cytometry analysis of human PBMCs processed with the EasySep™ Human CD19 Positive Selection Kit and labeled with Anti-Human CD19 Antibody, Clone HIB19, PE. Histograms show labeling of the PBMCs (Start) and isolated cells (Isolated). Labeling with a mouse IgG1, kappa PE isotype control antibody is shown in the bottom panel (open histogram).

Data for Unconjugated

Figure 6. Data for Unconjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI; filled histogram) or a mouse IgG1, kappa isotype control antibody followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Data for PerCP-Cy55-Conjugated

Figure 7. Data for PerCP-Cy55-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD19 Antibody, Clone HIB19, PerCP-Cy5.5 (filled histogram) or a mouse IgG1, kappa PerCP-Cy5.5 isotype control antibody (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, Alexa Fluor® 488
Catalog #
60005AD
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, APC
Catalog #
60005AZ, 60005AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, Biotin
Catalog #
60005BT, 60005BT.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, FITC
Catalog #
60005FI, 60005FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, PE
Catalog #
60005PE, 60005PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, PerCP-Cy5.5
Catalog #
60005PS.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19
Catalog #
60005
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, Alexa Fluor® 488
Catalog #
60005AD
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, APC
Catalog #
60005AZ, 60005AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, Biotin
Catalog #
60005BT, 60005BT.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, FITC
Catalog #
60005FI, 60005FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, PE
Catalog #
60005PE, 60005PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19, PerCP-Cy5.5
Catalog #
60005PS.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD19 Antibody, Clone HIB19
Catalog #
60005
Lot #
All
Language
English

更多信息

更多信息
Species Human, Non-Human Primate
Clone HIB19
Gene Id 930
Alternative Names B4
Isotype IgG1, kappa
Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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