产品号 #100-0880_C
Inhibits topoisomerase II
概述
Celastrol is a topoisomerase II inhibitor (IC50 = 7.41 μM) with neuroprotective and anti-inflammatory properties (Allison et al.; Lin et al.; Nagase et al.; Sethi et al.). It improves memory, learning, and psychomotor activity performance when administered in rats and may have therapeutic potential for treating neurodegenerative disorders such as Alzheimer's disease (Allison et al.). In addition, celastrol suppresses TNF-α-induced NF-κB activation and increases TNF-induced apoptosis in chronic myelogenous leukemia cells (Sethi et al.).
IMMUNOLOGY
· Induces apoptosis in human leukemia cells (Nagase et al.).
DISEASE MODELING
·Activates mitophagy and inhibits dopaminergic neuronal apoptosis in mice (Lin et al.).
Cell Type
Leukemia/Lymphoma Cells, Neurons
Area of Interest
Disease Modeling, Immunology, Neuroscience
CAS Number
34157-83-0
Chemical Formula
C29H38O4
Molecular Weight
450.6 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Celastrol Catalog #
100-0880 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Celastrol Catalog #
100-0880 Lot #
All Language
English Resources and Publications
Educational Materials (2)
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