产品号 #100-1164_C
Topoisomerase I inhibitor
概述
Inhibit proliferation of cancer cells by inhibiting topoisomerase I activity with camptothecin. Highly potent and cell-permeable, camptothecin inhibits topoisomerase I from religating broken DNA strands by forming a complex with topoisomerase I and DNA, which leads to cell death (Thomas et al.).
Camptothecin has been used for:
CANCER RESEARCH
· Can be used as an apoptosis induction positive control (cell-type dependent) in combination with Caspase-3/7 Activity Flow Cytometry Kit, Green (Catalog #100-0923), Caspase-3/7 Activity Plate Reader Assay Kits (Catalog #100-0922/100-0920), and FITC-C6-DEVD-FMK (Catalog #100-0924).
· Demonstrates cytotoxicity against several human tumor cell lines, including HT29, LOX, SKOV3, and SKVLB (Hentze et al.).
· Promotes degradation of mixed lineage leukemia 5 (MLL5) proteins in HCT116 cells (Cheng et al.).
· Induces apoptosis in various human cancer cell lines (HeLa, K562, CCRF-CEM, HCT-15, RBE, PC3, and C-33A) via a microRNA-125b-mediated mitochondrial pathway (Zeng et al.).
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
7689-03-4
Chemical Formula
C20H16N2O4
Molecular Weight
348.4 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Camptothecin Catalog #
100-1164 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Camptothecin Catalog #
100-1164 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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