产品号 #100-1125_C
Alkylating antineoplastic agent
概述
Inhibit proliferation of cancer cells by creating DNA breaks and DNA crosslinks with busulfan (Iwamoto et al.). Highly potent and cell-permeable, busulfan forms interstrand crosslinks between the DNA bases guanine and adenine and between guanine and guanine (Ponti et al.). DNA breakage induced by busulfan-mediated DNA crosslinking induces senescence in cells (Chen et al.).
Busulfan has been used for:
CANCER RESEARCH
· Induces senescence through bypassing the p53-p21 (Cip1/Waf1) pathway in murine bone marrow hematopoietic cells (Meng et al.).
· Induces senescence of WI38 fibroblasts in vitro through ERK-P38 pathways (Probin V et al.).
· Inhibits the growth and viability of osteosarcoma cells (U2OS and MG63) in vitro and in orthotopic implants in mice (Mei et al.).
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
55-98-1
Chemical Formula
C6H14O6S2
Molecular Weight
246.3 g/mol
Purity
≥ 98%
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Busulfan Catalog #
100-1125 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to 1,4-Butanediol dimethanesulfonate (Busulfan) which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov
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