产品号 #73972_C
Retinoid pathway activator; Activates pan-retinoic acid receptor
概述
BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).
DIFFERENTIATION
· Affects development of bronchial tubule formation in mice (Chazaud et al.).
· Inhibits activation of immature dendritic cells (Geissmann et al.).
CANCER RESEARCH
· Inhibits differentiation of leukemic blasts (Kamashev et al.).
Cell Type
Airway Cells, Cancer Cells and Cell Lines, Hematopoietic Stem and Progenitor Cells, Monocytes
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation
Area of Interest
Cancer, Disease Modeling, Immunology, Stem Cell Biology
CAS Number
215030-90-3
Chemical Formula
C₂₉H₂₄O₂
Purity
≥ 98%
Pathway
Retinoid
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
BMS 493 Catalog #
73972, 73974 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
BMS 493 Catalog #
73972, 73974 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Airway Epithelial Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Dendritic Cell Research
Resources and Publications
Educational Materials (4)
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