抗小鼠CD267(TACI)抗体,克隆8F10

抗小鼠CD267 (TACI)的大鼠单克隆IgG2a抗体

产品号 #(选择产品)

产品号 #60116_C

抗小鼠CD267 (TACI)的大鼠单克隆IgG2a抗体

总览

8F10抗体与小鼠CD267(跨膜激活剂和CAML相互作用蛋白,简称TACI)发生反应。TACI是TNF受体超家族中一个分子量约为30 kDa的III型跨膜蛋白,主要表达于脾脏B细胞成熟亚群的表面,包括过渡型2 (T2) B细胞和边缘区 (MZ) B细胞,以及浆细胞和浆母细胞。在体外和体内暴露于LPS的B细胞中,CD267的表达均上调。CD267通过与配体APRIL和BAFF相互作用调节B细胞的存活、增殖和成熟,在体液免疫中发挥重要作用。配体结合刺激包括NF-kappa-B在内的几种转录因子的激活,并已被证明可以诱导增殖或凋亡,这表明在B细胞的调节中具有双重作用。CD267 似乎还在响应胸腺非依赖性抗原的免疫球蛋白同型转换和 B 细胞分化中发挥重要作用。

亚型
一抗
 
靶抗原
CD267 (TACI)
 
活性物种
小鼠
 
偶联
APC,PE
 
宿主物种
大鼠
 
细胞类型
B 细胞
 
种属
小鼠
 
应用
流式细胞术
 
研究领域
免疫
 
克隆
8F10
 
基因编号
57916
 

Data Figures

Data for APC-Conjugated

Figure 1. Data for APC-Conjugated

(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE).

Data for PE-Conjugated

Figure 2. Data for PE-Conjugated

(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60116AZ, 60116AZ.1
Lot #
All
Language
English
Catalog #
60116PE, 60116PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60116AZ, 60116AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60116PE, 60116PE.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications

Educational Materials (2)

更多信息

更多信息
Species Mouse
Clone 8F10
Gene Id 57916
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