产品号 #60116_C
Rat monoclonal IgG2a antibody against mouse CD267 (TACI)
概述
The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ~30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts. Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo. CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF. Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells. CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens.
Subtype
Primary Antibodies
Target Antigen
CD267 (TACI)
Reactive Species
Mouse
Conjugation
APC, PE
Host Species
Rat
Cell Type
B Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
8F10
Gene ID
57916
Data Figures
Figure 1. Data for APC-Conjugated
(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE).
Figure 2. Data for PE-Conjugated
(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC Catalog #
60116AZ, 60116AZ.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE Catalog #
60116PE, 60116PE.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC Catalog #
60116AZ, 60116AZ.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE Catalog #
60116PE, 60116PE.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for B Cell Research
Workflow Stages for Total Lymphocyte Research
Resources and Publications
Educational Materials (2)
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