产品号 #60116_C
抗小鼠CD267 (TACI)的大鼠单克隆IgG2a抗体
8F10抗体与小鼠CD267(跨膜激活剂和CAML相互作用蛋白,简称TACI)发生反应。TACI是TNF受体超家族中一个分子量约为30 kDa的III型跨膜蛋白,主要表达于脾脏B细胞成熟亚群的表面,包括过渡型2 (T2) B细胞和边缘区 (MZ) B细胞,以及浆细胞和浆母细胞。在体外和体内暴露于LPS的B细胞中,CD267的表达均上调。CD267通过与配体APRIL和BAFF相互作用调节B细胞的存活、增殖和成熟,在体液免疫中发挥重要作用。配体结合刺激包括NF-kappa-B在内的几种转录因子的激活,并已被证明可以诱导增殖或凋亡,这表明在B细胞的调节中具有双重作用。CD267 似乎还在响应胸腺非依赖性抗原的免疫球蛋白同型转换和 B 细胞分化中发挥重要作用。
亚型
一抗
靶抗原
CD267 (TACI)
活性物种
小鼠
偶联
APC,PE
宿主物种
大鼠
细胞类型
B 细胞
种属
小鼠
应用
流式细胞术
研究领域
免疫
克隆
8F10
基因编号
57916
Figure 1. Data for APC-Conjugated
(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, APC and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, PE (Catalog #60035PE).
Figure 2. Data for PE-Conjugated
(A) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with Anti-Mouse CD267 (TACI) Antibody, Clone 8F10, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ). (B) Flow cytometry analysis of immunized C57BL/6 mouse splenocytes labeled with a rat IgG2a, kappa isotype control antibody, PE and Anti-Mouse CD138 (Syndecan-1) Antibody, Clone 281-2, APC (Catalog #60035AZ).
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Species | Mouse |
---|---|
Clone | 8F10 |
Gene Id | 57916 |
免疫磁珠负选未标记的小鼠Pan-B(CD19+、CD19+CD138+、CD138+)细胞
抗小鼠 CD138(syndecan-1)的大鼠单克隆 IgG2a 抗体
大鼠单克隆IgG2a, kappa同型对照抗体
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