产品号 #100-1341_C
Rabbit polyclonal antibody against human, mouse, rat TBR1
概述
This rabbit polyclonal antibody reacts with human, mouse and rat T-box brain 1 (TBR1), a transcription factor highly expressed and involved in human development; mutations of the T-box gene have been linked to developmental disorders as well as the manifestation of certain cancers. Use this polyclonal antibody in applications requiring detection of TBR1, such as ELISA, western blot (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and immunofluorescence (IF). This antibody clone has been verified for labeling TBR1-positive cortical neurons in hPSC-derived cerebral organoids generated with STEMdiff™ Cerebral Organoid Kit (Catalog #08570) and STEMdiff™ Cerebral Organoid Maturation Kit (Catalog #08571).
The T-box transcription factor family consists of five subfamilies, with the TBR1 family of proteins responsible for brain development, primarily through the function of T-box proteins that act as transcriptional activators and inhibitors. In particular, the function of TBR1 in brain development is primarily facilitated by the differentiation of neural stem cells (NSCs) in both developing and adult brains. Structurally, T-box transcription factors contain a conserved DNA-binding motif named T-box domain, spanning 180-200 amino acid residues to bind DNA. Studies involving TBR1-deficient mice found defects in the frontal cortex and layer 6 differentiation.
Subtype
Primary Antibodies
Target Antigen
TBR1
Alternative Names
IDDAS, TBR-1, TES-56
Reactive Species
Human, Mouse, Rat
Conjugation
Unconjugated
Host Species
Rabbit
Cell Type
Neural Cells, PSC-Derived, Neurons
Species
Human
Application
Immunocytochemistry
Area of Interest
Neuroscience, Stem Cell Biology
Clone
Poly
Gene ID
10716
Isotype
Not Applicable
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
