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抗人 SOX2 (ANOP3) 抗体，克隆 2E1

兔单克隆抗体，抗人、小鼠、大鼠SOX2
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产品号 #100-1339_C

兔单克隆抗体，抗人、小鼠、大鼠SOX2

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总览
实验数据
产品说明书及文档
应用领域
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总览

兔单克隆抗体（克隆号 2E1）可识别人、小鼠和大鼠的性别决定区 Y-box 2（SOX2）蛋白，SOX2 属于 SOX 转录因子家族。该重组抗体适用于多种检测 SOX2 的实验应用，包括 ELISA、蛋白质印迹（WB）、免疫组织化学（IHC）、免疫细胞化学（ICC）和免疫荧光（IF）。本抗体已验证可用于标记以下来源的 SOX2 阳性细胞：采用 STEMdiff™ SMADi 神经诱导试剂盒（产品号 #08581）和 STEMdiff™ 神经祖细胞培养基（产品号 #05833）生成的人类多能干细胞（hPSC）来源的神经干细胞和祖细胞，以及使用 mTeSR™ Plus（产品号 #100-0276）培养的人类多能干细胞。

SOX2 在维持胚胎干细胞（ES 细胞）多能性方面发挥关键作用，其表达水平需精确调控；无论过高还是过低，均可导致多能性的丧失。此外，SOX2 对胚胎早期多能细胞的发育至关重要，是胚胎发育不可或缺的因子。SOX 转录因子家族成员均含有高度保守的高迁移率族（HMG）DNA 结合结构域。SOX2 属于 SOXB1 亚家族，与 SOX1 和 SOX3 同属一类。SOX 蛋白通过核定位调控细胞分化与发育，其核定位信号（NLS）位于 HMG 结构域的两端。当这些区域发生突变时，可能引发肿瘤或多种发育性疾病。

亚型
一抗
 
靶抗原
Sox-2
 
别名
ANOP3，MCOPS3
 
活性物种
人，小鼠，大鼠
 
偶联
未偶联的
 
宿主物种
兔
 
细胞类型
神经细胞，PSC衍生，神经干/祖细胞，多能干细胞
 
种属
人
 
应用
免疫细胞化学
 
研究领域
神经科学，干细胞生物学
 
克隆
2E1
 
基因编号
6657
 
同种型
IgG
 

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Data Figures

Figure 1. Human Neural Progenitor Cells Stained with Anti-Human SOX2 Antibody, Polyclonal

(A) Human neural progenitor cells (NPCs) were generated from induced pluripotent stem (iPS) cells using STEMdiff™ SMADi Neural Induction Kit and STEMdiff™ Neural Progenitor Medium and cultured on Corning® Matrigel®. NPCs were then fixed and labeled with Anti-Human SOX2 Antibody, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (green) (Catalog #100-1082). Inset shows NPCs labeled with a rabbit IgG isotype control antibody, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (with DAPI staining). (B) DAPI (blue) counterstaining of the cells shown in figure (A); nuclear localization of SOX2 is evident.

Figure 2. Human iPS Cells Stained with Anti-Human SOX2 Antibody, Polyclonal

(A) Human iPS cells were cultured in mTeSR™ Plus on Corning® Matrigel®, then fixed and labeled with Anti-Human SOX2 Antibody, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (green) (Catalog #100-1082). Inset shows iPS cells labeled with a rabbit IgG isotype control antibody, followed by Goat Anti-Rabbit IgG (H+L) Antibody, Polyclonal, iFluor™ 488 (with DAPI staining). (B) DAPI (blue) counterstaining of the cells shown in figure (A); nuclear localization of SOX2 is evident.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human SOX2 (ANOP3) Antibody, Clone 2E1
Catalog #
100-1339
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human SOX2 (ANOP3) Antibody, Clone 2E1
Catalog #
100-1339
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Clone 2E1
Gene Id 6657
Alternative Names ANOP3, MCOPS3
Isotype IgG
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