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抗人穿孔素抗体，克隆deltaG9

抗人穿孔素的小鼠单克隆IgG2b抗体
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产品号 #100-1455_C

抗人穿孔素的小鼠单克隆IgG2b抗体

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总览
实验数据
产品说明书及文档
应用领域
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总览

抗人穿孔素的小鼠单克隆抗体（克隆deltaG9）可特异性识别人穿孔素。穿孔素是一种分子量约为70 kDa的蛋白质，由四个结构域组成：与其功能相关的N端和C端，以及两个与补体蛋白C6 - C9相似的中央结构域。作为穿孔素/颗粒酶凋亡途径的关键效应分子，穿孔素由自然杀伤细胞（NK细胞）和细胞毒性T细胞（CTL）分泌。当效应细胞接触靶细胞时，穿孔素单体释放并在靶细胞膜上聚合形成跨膜孔道，破坏其膜完整性。这一过程使颗粒酶B（granzyme B）得以进入靶细胞，从而启动病毒感染细胞或转化细胞的凋亡程序。

靶抗原
Perforin
 
别名
细胞毒素；淋巴细胞孔形成蛋白；P1；穿孔素 1；PFP
 
活性物种
人
 
偶联
Biotin 或 生物素，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
NK 细胞，T 细胞，CD8+
 
种属
人
 
应用
流式细胞术
 
研究领域
免疫
 
克隆
deltaG9
 
基因编号
5551
 
同种型
IgG2b，kappa
 

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Data Figures

Flow Cytometry Analysis Of Human PBMCs Labeled With Kappa FITC Isotype Control and Clone deltaG9, FITC Antibodies

Figure 1. Data for Anti-Human Perforin Antibody, Clone deltaG9, FITC

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Mouse IgG2b, kappa FITC Isotype Control antibody and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with anti-human perforin Antibody, Clone deltaG9, FITC and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ).

Flow Cytometry Analysis Of Human PBMCs Labeled With Kappa PE Isotype Control and Clone deltaG9, PE Antibodies

Figure 2. Data for Anti-Human Perforin Antibody, Clone deltaG9, PE

(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Mouse IgG2b, kappa PE Isotype Control antibody and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with anti-human perforin Antibody, Clone deltaG9, PE and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, FITC
Catalog #
100-1455
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, PE
Catalog #
100-1456
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, Biotin
Catalog #
100-1458
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9
Catalog #
100-1457
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, FITC
Catalog #
100-1455
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, PE
Catalog #
100-1456
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9, Biotin
Catalog #
100-1458
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human Perforin Antibody, Clone deltaG9
Catalog #
100-1457
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Clone deltaG9
Gene Id 5551
Alternative Names Cytolysin, lymphocyte pore forming protein, P1, perforin 1, PFP
Isotype IgG2b, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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