产品号 #100-1455_C
Mouse monoclonal IgG2b antibody against human perforin
概述
This mouse monoclonal antibody (clone deltaG9) reacts with human perforin. Perforin is an ~70 kDa protein consisting of four domains: the N- and C-termini, which are related to its function, and two central domains that share similarities to complement proteins C6 - C9. Perforin is involved in the perforin/granzyme apoptosis pathway and is produced by natural killer and cytotoxic T cells. Upon contact with a target cell, perforin monomers are released and aggregate to form pores in the membrane of the target cell, disrupting its membrane integrity. This allows granzyme B to enter the target cell and initiate apoptosis of virally infected and transformed cells.
Target Antigen
Perforin
Alternative Names
Cytolysin, lymphocyte pore forming protein, P1, perforin 1, PFP
Reactive Species
Human
Conjugation
Biotin, FITC, PE, Unconjugated
Host Species
Mouse
Cell Type
NK Cells, T Cells, CD8+
Species
Human
Application
Flow Cytometry
Area of Interest
Immunology
Clone
deltaG9
Gene ID
5551
Isotype
IgG2b, kappa
Data Figures
Figure 1. Data for Anti-Human Perforin Antibody, Clone deltaG9, FITC
(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Mouse IgG2b, kappa FITC Isotype Control antibody and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with anti-human perforin Antibody, Clone deltaG9, FITC and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ).
Figure 2. Data for Anti-Human Perforin Antibody, Clone deltaG9, PE
(A) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Mouse IgG2b, kappa PE Isotype Control antibody and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ). (B) Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with anti-human perforin Antibody, Clone deltaG9, PE and anti-human CD56 antibody, clone HCD56, APC (Catalog #60021AZ).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, FITC Catalog #
100-1455 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, PE Catalog #
100-1456 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, Biotin Catalog #
100-1458 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9 Catalog #
100-1457 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, FITC Catalog #
100-1455 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, PE Catalog #
100-1456 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9, Biotin Catalog #
100-1458 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human Perforin Antibody, Clone deltaG9 Catalog #
100-1457 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
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