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抗人p63（deltaN）抗体，克隆Poly6190

抗人p63（deltaN）的兔多克隆抗体
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产品号 #60154_C

抗人p63（deltaN）的兔多克隆抗体

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实验数据
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总览

Poly6190抗体可特异性识别人源p63蛋白的deltaN亚型。p63作为p53转录因子家族成员，通过可变剪接产生两类功能迥异的亚型。TA亚型（TA p63-α、-β、-γ）具有N端转录激活域，而deltaN亚型（deltaN p63-α、-β、-γ）缺失转录激活域。TA亚型能够激活p53靶基因转录，同时拮抗p53蛋白功能。deltaN亚型通常对TA亚型具有显性负调控作用，抑制其功能。p63蛋白位于细胞核内，在上皮干细胞再生、表皮形态发生、肢体发育和上皮分层中发挥重要作用。

亚型
一抗
 
靶抗原
p63 (deltaN)
 
别名
TP63；肿瘤蛋白 P63
 
活性物种
人
 
偶联
未偶联的
 
宿主物种
兔
 
细胞类型
气道细胞，真皮细胞
 
应用
免疫细胞化学，免疫荧光，免疫组化，Western印迹
 
研究领域
上皮细胞研究，干细胞生物学
 
克隆
Not applicable (poly6190)
 
基因编号
8626
 
同种型
IgG
 

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Data Figures

(A) Primary human airway epithelial cells were expanded in a submerged culture with PneumaCult™-Ex Medium (Catalog #05008) and labeled with Anti- Human p63 (deltaN) Antibody, Clone Poly6190, followed by a goat anti-rabbit IgG antibody, Alexa Fluor® 594. (B) DAPI counterstaining of the cells shown in figure (A). (C) Primary human airway epithelial cells cultured in PneumaCult™-ALI Medium (Catalog #05001) at the air-liquid interface were cryo-sectioned and labeled with Anti-Human p63 (deltaN) Antibody, Clone Poly6190 (red), followed by a goat anti-rabbit IgG antibody, Alexa Fluor® 594 (red), and antihuman NGF Receptor/p75NTR (CD271) antibody, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488 (green). (D) Western blot analysis of non-transfected HEK293 cell lysates (negative control; lane 1) and p63 (deltaN)-transfected HEK293 cell lysates (lane 2). Lysates were resolved by electrophoresis, transferred to nitrocellulose, and probed with Anti-Human p63 (deltaN) Antibody, Clone Poly6190. Proteins were visualized using an HRP-conjugated donkey anti-rabbit IgG secondary antibody and chemiluminescence detection.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human p63 (deltaN) Antibody, Clone Poly6190
Catalog #
60154
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human p63 (deltaN) Antibody, Clone Poly6190
Catalog #
60154
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (2)

Pulmonary Research
Brochure
Pulmonary Research
Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research

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更多信息
Clone Not applicable (poly6190)
Gene Id 8626
Alternative Names TP63, Tumor protein P63
Isotype IgG
Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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