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抗人 IL-4 抗体，克隆 MP4-25D2

抗人IL-4大鼠单克隆IgG抗体
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产品号 #100-1452_C

抗人IL-4大鼠单克隆IgG抗体

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总览
实验数据
产品说明书及文档
应用领域
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总览

该大鼠单克隆抗体（克隆号 MP4-25D2）可与人白细胞介素 4 (IL-4) 发生反应。IL-4 是一种分子量约为 15 kDa 的蛋白质，主要由四螺旋束组成（Powers et al.），由多种免疫细胞产生，包括辅助性 T 细胞 2 (Th2)、嗜碱性粒细胞、嗜酸性粒细胞和肥大细胞（Gadani et al.）。它对 IL-4 受体 α (IL-4Rα) 链具有高亲和力，该链可与常见的 γ 链 (γc) 或 IL-13 受体 α 1 (IL-13Rα1) 二聚化，从而激活下游 JAK-STAT 信号通路 (Heller at al.)。 IL-4 参与 CD4+ T 淋巴细胞向 Th2 细胞的分化（Silva-Filho et al.）、B 细胞向 IgE 的类型转换（Geha et al.）以及通过替代途径用 IL-13 激活 M2 巨噬细胞（Gordon et al.）。

靶抗原
IL-4
 
别名
B细胞刺激因子1，BCDF，BCGF，BSF-1，白细胞介素-4
 
活性物种
人
 
偶联
APC，PE，未偶联的
 
宿主物种
大鼠
 
细胞类型
T 细胞，CD4+
 
种属
人
 
应用
流式细胞术
 
研究领域
免疫
 
克隆
MP4-25D2
 
基因编号
3565
 
同种型
IgG1，kappa
 

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Data Figures

Flow Cytometry Analysis Of Unstimulated And Stimulated Human PBMCs Labeled With Anti-Human IL-4 Antibody, Clone MP4-25D2

Figure 1. Data for Anti-Human IL-4 Antibody, Clone MP4-25D2, PE

(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, PE and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, PE and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).

Flow Cytometry Analysis Of Unstimulated And Stimulated Human PBMCs Labeled With Anti-Human CD8a Antibody, Clone RPA-T8, PE

Figure 2. Data for Anti-Human IL-4 Antibody, Clone MP4-25D2, APC

(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, APC and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, APC and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, PE
Catalog #
100-1452
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2
Catalog #
100-1454
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, APC
Catalog #
100-1453
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, PE
Catalog #
100-1452
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2
Catalog #
100-1454
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, APC
Catalog #
100-1453
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Clone MP4-25D2
Gene Id 3565
Alternative Names B cell stimulatory factor 1, BCDF, BCGF, BSF-1, interleukin-4
Isotype IgG1, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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