产品号 #100-1452_C
Rat monoclonal IgG antibody against human IL-4
概述
This rat monoclonal antibody (clone MP4-25D2) reacts with human interleukin 4 (IL-4). IL-4 is an ~15 kDa protein primarily composed of a four-helix bundle (Powers et al.) and is produced by a host of immune cells including T helper 2 (Th2) cells, basophils, eosinophils, and mast cells (Gadani et al.). It exhibits high affinity for the IL-4 receptor alpha (IL-4Rα) chain, which dimerizes with either the common gamma chain (γc) or IL-13 receptor alpha 1 (IL-13Rα1), leading to activation of downstream JAK-STAT signaling (Heller at al.). IL-4 is involved in the differentiation of CD4+ T lymphocytes into Th2 cells (Silva-Filho et al.), class switching of B cells to IgE (Geha et al.), and activation of M2 macrophages with IL-13 via an alternative pathway (Gordon et al.).
Target Antigen
IL-4
Alternative Names
B cell stimulatory factor 1, BCDF, BCGF, BSF-1, interleukin-4
Reactive Species
Human
Conjugation
APC, PE, Unconjugated
Host Species
Rat
Cell Type
T Cells, CD4+
Species
Human
Application
Flow Cytometry
Area of Interest
Immunology
Clone
MP4-25D2
Gene ID
3565
Isotype
IgG1, kappa
Data Figures
Figure 1. Data for Anti-Human IL-4 Antibody, Clone MP4-25D2, PE
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, PE and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, PE and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).
Figure 2. Data for Anti-Human IL-4 Antibody, Clone MP4-25D2, APC
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, APC and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-4 Antibody, Clone MP4-25D2, APC and anti-human CD8a antibody, clone RPA-T8, PE (Catalog #60022PE).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, PE Catalog #
100-1452 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2 Catalog #
100-1454 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, APC Catalog #
100-1453 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, PE Catalog #
100-1452 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2 Catalog #
100-1454 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IL-4 Antibody, Clone MP4-25D2, APC Catalog #
100-1453 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Workflow Stages
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