抗人 IL-2 抗体,克隆 MT8G10

小鼠单克隆IgG1抗体,抗人、食蟹猴IL-2

产品号 #(选择产品)

产品号 #100-1464_C

小鼠单克隆IgG1抗体,抗人、食蟹猴IL-2

总览

该小鼠单克隆抗体(克隆 MT8G10)可与人白细胞介素 2(IL-2)发生反应。IL-2 是一种约 16 kDa 的细胞因子,由一个四α-螺旋束组成(Arenas-Ramirez et al.),主要由 CD4+ T 辅助细胞(Th)产生,少量由 CD8+ T 细胞、自然杀伤(NK)细胞和 NK T 细胞产生(Boyman & Sprent)。它与 IL-2 受体 α(IL-2Rα;CD25)结合,再与 IL-2Rꞵ (CD122)和 γc (CD132)亚基复合(Malek & Castro),并引起 JAK1/3、P13K-AKT 和 MAPK 信号通路的激活(Arenas-Ramirez et al.)。IL-2 介导 T 细胞的生长和增殖,促进 CD4+ T 细胞向 Th1 和 Th2 细胞分化,促进 CD8+ T 细胞和 NK 细胞的细胞溶解活性,并驱动 CD4+FOXP3+ 调节性 T 细胞的发育(Liao et al.)。

靶抗原
IL-2
 
别名
IL2,白细胞介素2,白细胞介素-2,淋巴因子,T细胞生长因子,TCGF
 
活性物种
人,其它细胞系
 
偶联
Biotin 或 生物素,FITC
 
宿主物种
小鼠
 
细胞类型
NK 细胞,T 细胞,CD4+,T 细胞,CD8+
 
种属
人,其它细胞系
 
应用
流式细胞术
 
研究领域
免疫
 
克隆
MT8G10
 
基因编号
3558
 
同种型
IgG1
 

Data Figures

Flow Cytometry Analysis Of Unstimulated And Stimulated Human PBMCs Labeled With Anti-Human IL-2 Antibody, Clone MT8G10 FITC

Figure 1. Data for Anti-Human IL-2 Antibody, Clone MT8G10 FITC

(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-2 Antibody, Clone MT8G10, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IL-2 Antibody, Clone MT8G10, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1464
Lot #
All
Language
English
Catalog #
100-1465
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1464
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1465
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human, Other
Clone MT8G10
Gene Id 3558
Alternative Names IL2, interleukin 2, interleukin-2, lymphokine, T cell growth factor, TCGF
Isotype IgG1
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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