产品号 #100-1459_C
Mouse monoclonal IgG1 antibody against human IFN-gamma
概述
This mouse monoclonal antibody (clone 1-D1K) reacts with human interferon-gamma (IFN-γ). IFN-γ is an ~17 kDa protein produced in response to mitogenic and antigenic stimuli by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ functions as a homodimer that is composed of interconnecting alpha-helices (Thiel et al.), which bind to the alpha subunit of the IFN-γ receptor (IFNGR) on target cells, resulting in receptor crosslinking and activation of JAK-STAT signaling (Kak et al.). IFN-γ mediates many cellular effects, including upregulation of class I and II antigen presentation pathways, antiviral and antimicrobial mechanisms, antiproliferative and apoptotic effects, immunomodulation, and leukocyte trafficking (Schroder et al.).
Target Antigen
IFNγ
Alternative Names
IFN-γ, immune interferon, interferon gamma, type II interferon
Reactive Species
Human, Non-Human Primate
Conjugation
FITC, Unconjugated
Host Species
Mouse
Cell Type
NK Cells, T Cells
Species
Human, Non-Human Primate
Application
Flow Cytometry
Area of Interest
Immunology
Clone
1-D1K
Gene ID
3458
Isotype
IgG1
Data Figures
Figure 1. Data for Anti-Human IFN-gamma Antibody, Clone 1-D1K, FITC
(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IFN-gamma Antibody, Clone 1-D1K, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IFN-gamma Antibody, Clone 1-D1K, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human IFN-gamma Antibody, Clone 1-D1K Catalog #
100-1460 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human IFN-gamma Antibody, Clone 1-D1K, FITC Catalog #
100-1459 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IFN-gamma Antibody, Clone 1-D1K Catalog #
100-1460 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human IFN-gamma Antibody, Clone 1-D1K, FITC Catalog #
100-1459 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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