抗人IFN-gamma 抗体,克隆 1-D1K

小鼠单克隆IgG1抗体,抗人IFN-gamma

产品号 #(选择产品)

产品号 #100-1459_C

小鼠单克隆IgG1抗体,抗人IFN-gamma

总览

该小鼠单克隆抗体(克隆 1-D1K)能与人干扰素-γ(IFN-γ)反应。IFN-γ 是一种约 17 kDa 的蛋白质,由 T 细胞和 NK 细胞在有丝分裂和抗原刺激下产生,树突状细胞和巨噬细胞产生的量较少。IFN-γ 受 IL-12 和 IL-18 等细胞因子的控制,这些细胞因子是在感染时分泌的(Schroder et al.)。IFN-γ 是由相互连接的α-螺旋组成的同源二聚体(Thiel et al.),它与靶细胞上 IFN-γ 受体(IFNGR)的α亚基结合,导致受体交联并激活 JAK-STAT 信号传导(Kak et al.)。IFN-γ 可介导多种细胞效应,包括上调 I 类和 II 类抗原递呈途径、抗病毒和抗微生物机制、抗增殖和细胞凋亡作用、免疫调节和白细胞转运(Schroder et al.)。

靶抗原
IFNγ
 
别名
IFN-γ,免疫干扰素,干扰素γ,Ⅱ型干扰素
 
活性物种
人,非人灵长类
 
偶联
FITC,未偶联的
 
宿主物种
小鼠
 
细胞类型
NK 细胞,T 细胞
 
种属
人,非人灵长类
 
应用
流式细胞术
 
研究领域
免疫
 
克隆
1-D1K
 
基因编号
3458
 
同种型
IgG1
 

Data Figures

Flow Cytometry Analysis Of Unstimulated And Stimulated Human PBMCs Labeled With Anti-Human IFN-gamma Antibody, Clone 1-D1K, FITC

Figure 1. Data for Anti-Human IFN-gamma Antibody, Clone 1-D1K, FITC

(A) Flow cytometry analysis of unstimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IFN-gamma Antibody, Clone 1-D1K, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1). (B) Flow cytometry analysis of PMA/ionomycin-stimulated human peripheral blood mononuclear cells (PBMCs) labeled with anti-human IFN-gamma Antibody, Clone 1-D1K, FITC and anti-human CD8a antibody, clone RPA-T8, APC (Catalog #60022AZ.1).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1460
Lot #
All
Language
English
Catalog #
100-1459
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1460
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1459
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human, Non-Human Primate
Clone 1-D1K
Gene Id 3458
Alternative Names IFN-γ, immune interferon, interferon gamma, type II interferon
Isotype IgG1
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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